Abstract: In the context of the manufacturing industry returning to the major developed countries and the increasing participation rate of the mainland and the entire Southeast Asian in the global value chain, Hong Kong is facing the threat of losing competitive advantage due to the Industrial Hollowing. Therefore, Hong Kong's industrial structure is in urgent need of transformation and upgrading, and re-industrialization is imperative. Based on the definition of re-industrialization, the article analyzes the characteristics of Hong Kong's industrial structure and the influence of industrial hollowing out through statistical data, and then proves the necessity of re-industrialization in Hong Kong. The facts are used to demonstrate the impact of the value chain of intelligent manufacturing on the development of Hong Kong's industry, the advantages of Hong Kong's re-industrialization and the feasibility of re-industrialization in Hong Kong from the perspective of intelligent manufacturing. On this basis, Hong Kong's re-industrialization in the field of intelligent manufacturing was conducted through case studies.