Abstract: Cross-border M&A is an effective way for enterprises to acquire knowledge, and it is also an important approach for enterprises to obtain OIL advantages and achieve internationalization. Inter-organizational compatibility is a key variable affecting knowledge transfer in cross-border M&A, and different types of knowledge seem to be intrinsically linked to OIL advantages in the enterprises. In cross-border mergers and acquisitions, how should enterprises effectively improve knowledge transfer by improving inter-organizational compatibility, thereby enhancing OIL advantages? Based on the congruence theory and eclectic theory, this paper matches technological knowledge, managerial knowledge, market knowledge with ownership advantages, internalization advantages, and location advantages. On this basis, this study combines technological compatibility, cultural compatibility, strategic compatibility, technological knowledge, managerial knowledge and market knowledge into a research framework, an empirical analysis of 182 Chinese cross-border M&A enterprises was conducted using SPSS22.0 and LISREL8.70 software. The results clearly indicate that different dimensions of compatibility have a positive impact on the various types of knowledge transfer in cross-border M&A, which in turn enhances the OIL advantages. Specifically, technological compatibility has the greatest impact on the technological knowledge, which in turn enhances the ownership advantages; cultural compatibility is the strongest promotion of managerial knowledge, and thus the internalization advantages are advanced; strategic compatibility is the most helpful to promote market knowledge, thereby facilitating the location advantages.