Abstract: Due to multiple factors, there are countless challenges for technology-based start-ups to confront during pursuing high quality development. It is significant for them to accumulate and utilize essential resources. Yet the inner mechanism of entrepreneurial network affecting new venture growth and the micro process of resource orchestration are not well documented. A multi-case study of four technology-based start-ups is conducted to analyze the antecedents and inner logic of resource orchestration, and the mechanism of resource orchestration influencing venture growth is investigated. Based on sophisticated work, a structure-action-performance theoretical model is proposed. The results show that: (1) entrepreneurial network is essential for technology-based start-ups’ growth; (2) resource orchestration can be implemented based on entrepreneurial network; (3) resource orchestration are iterative and impenetrate the whole process of technology-based start-ups development, for resource orchestration are resource-focused actions that can bundle resource to formulate resource portfolio and make essential resource balanced to promote venture growth.