Abstract: Based on a quasi-natural experiment and a difference-in -difference model, the thesis explores the impact of comprehensive innovation reform experimental policy on patent output, and discusses the influence of regional heterogeneity and urban administrative level heterogeneity on policy effect. The results show that the comprehensive innovation reform experimental policy significantly promotes the patent output. Science and technology fiscal expenditure, information infrastructure and urban population significantly promote the patent output. Regional heterogeneity and urban administrative hierarchy heterogeneity affect the policy effect. To be specific, the comprehensive innovation reform experimental policy significantly promotes the patent output of eastern cities and prefecture-level cities. Significant differences exist between eastern and non-eastern cities in the effects of talent reserve and foreign investment.