Abstract: Evidence-based policy-making helps to improve the scientificity of government decision-making and the quality of public policy, especially in the state of public crisis. In the current Covid-19 response, how to improve the use of research evidence in decision-making has become a highly concerned and urgent problem for international academic and practical circles. Using the method of fuzzy set qualitative comparative analysis, this paper attempts to analyze the complex causal mechanism of multiple factors affecting the use of research evidence in the Policy-making of Covid-19 Response. The results show that the use of research evidence in the Policy-making of Covid-19 Response is affected by multiple complex factors, with two driving paths of high research evidence use and four driving paths of non high research evidence use. The attitude of policy makers towards research evidence, the system of political party cooperation and consultation, and the amount of research evidence have great influence on Covid-19 plays an important role in promoting the use of research evidence in decision-making. On this basis, this paper discusses the strategies that can be taken to provide reference for promoting the use of research evidence in the Policy-making of Covid-19 Response.