Abstract: Abstract: this paper discusses the influence of digital economy on the pattern of urban specialization. In theory, the development of digital economy promotes the change of urban specialization pattern by expanding and increasing the share of non-tradable goods, alleviating the constraints of time and space on economic activities and digital spatial allocation of resources to expand the market scale. Empirically, based on the quasi-natural experiment of "National Smart City" policy, this paper uses the double difference measurement method to identify the impact of digital economy on urban specialization pattern. The results show that digital economy promotes urban employment agglomeration and industrial specialization. From the perspective of center-periphery theory, the promotion of urban specialization and the formation of industrial comparative advantage of digital economy are mainly concentrated in central cities, and the impact on the level of specialization of peripheral cities is not significant. The research of this paper promotes the understanding of the influence of digital economy on economic geography and the acceleration of digital transformation of city government in the era of digital economy.