Abstract: The emergence of academic entrepreneurship is the inevitable result of the expansion of university basic research to the field of industrial technology. It has become an important path for developed countries to build core competitiveness. However, the existing research generally regards the technological learning at the academic entrepreneurship laboratory as the whole of technological learning system, and fails to understand the internal mechanism and general outline of academic entrepreneurship technological learning. By analyzing the technological learning process of academic entrepreneurship, this paper finds that the technological learning system of academic entrepreneurship is composed of the "learning by doing" learning subsystem at the laboratory end and the "learning by using" learning subsystem at the user end. The two subsystems are different, complementary and irreplaceable, and together constitute the innovation and iteration mechanism of circular feedback. Moreover, the academic entrepreneurship team's leading and controlling the "learning by using" subsystem will effectively improve the innovation iteration efficiency, and the government provide new technological scenarios in a targeted and organized way, which will effectively promote the academic entrepreneurship team to achieve independent innovation and development.