Abstract: Science and technology are reciprocal and synergistically developing. Previous researches have explored the interaction mode and relationship between science and technology mainly from the perspective of domain development, but rarely from the perspective of specific innovation subjects. As papers and patents are typical representations of science and technology, taking innovation-oriented enterprises in genetic engineering field as an example, this paper constructs a science-technology network with papers and patents as nodes. Adapting the knowledge network analysis method, we combine the semantic features of nodes with the structure features of the network to reveal the linkages between science and technology in innovation-oriented enterprises. The results show that: (1) Science to technology conversion is higher in more innovative enterprises, but excessive size of science and technology leads to lower conversion rates; (2) Science and technology linkage within innovative enterprises are more advantageous compared to that across enterprises, as it allows for a more rapid flow of knowledge from science to technology, and more innovative firms are able to make linkages across a wider range of science and technology fields; (3) Domain diversity of science and technology linkages in innovative firms is associated with domain balance and the heterogeneous capability of enterprises, whereas domain balance is associated with only domain diversity. This study can provide management insights for innovative firms to conduct basic research and promote science and technological innovation.