Abstract: The concept of “world scientific activity center” was proposed by J. D. Bernal in the year of 1957, and have raised many interests from globle researchers. Study the matastasis rule of world scientific activity center is of importance to the policy makers for establishing the R&D development strategies. Most of the previous studies analyzed the matastasis rule of the world scientific activity center based on the researchers’ achievements. However, this method is not suitable at present under the background of global integration, while the collaboration among researchers increasing greatly. The transnational flows of high-quality scientists was regarded as can be the representive of vital knowledge spreading. Previous researches have validated this based on study the matastasis of Nobel prize winners or the authors of top journals. They contributed to understand the related rule of world scientific activity center at present. However, these studies also have some limitations. Such as they only studied a small group of researchers, thus the whole phenomenon of the scientists transfer could not be reflected. Based on the above analysis, this paper collects the scientific papers published from 1921 to 2020 in the Scopus database, extracts the transnational flow sequence of each high-quality scientists, which are the top1% h-index researchers in each disciplines of the Scopus database, from these papers, and systematically analyzes the matastasis rule of world scientific activity center in the 100 years both in the whole level and the disciplinary level. Specially, the ten important disciplines including agricultural and biological sciences, biochemistry, genetics and molecular biolog, physics and astronomy, multidisciplinary, neuroscience, immunology and microbiology, materials science, chemistry, medicine, and engineering are selected into study, due to their intimate relationships with the world scientific activity center proven by previous studies. Results show that, first, the world scientific center or disciplinary activity center is not sole. There could be more than one world scientific center or disciplinary activity center in the same period. For example, the USA, UK, Germany and Italy have been the world scientific activity centers in multible periods and among various disciplines. Second, both the world scientific activity center and the disciplinary activity center could transfer over time, and the transfer direction was not one-way. Besides, the transfer process of these two kind of centers are synchronous. When a region was the world scientific activity center, it was often several disciplines’ activity center, and vice versa. For example, the USA was almost all the disciplines’ activity centers in the entire period. Thus the world scientific activity center could be regarded as the additive effect of the different disciplines. Third, different disciplines contributed differently to the formation of scientific activity center in the certain period. The diversified development of science and the interdisciplinary integration have moderated the difference, it is hard to distinguish which disciplines have the higher contribution degrees. Last, China has been the world scientifc activity center since the year of 2004. But it still has a significant gap from the developed countries. The disciplines of multidisciplinary, medicine and neuroscience still need to be developed in the future. Specially, significant attentions should be paid to the emerged scientific and technological domains, the R&D input should be raised and the balance development among disciplines should be also sidelined in the future.