Abstract: The evolution of science communication models has progressed from the ‘deficit model’ to the ‘Public Engage in Science’. Both of them reflects how science communicators share scientific information with the public. As artificial intelligence (AI) technology is being applied in the media industry, intelligent media has established a new science communication system. This paper analyzes the features of science communication of intelligent media, which is interactivity, dynamics, precision, and self-learning, along with the pluralism of communicators as well as the multiplicity of transmission channels and spaces. The interactive science communication model within intelligent media is designed on this basis. Subsequently, a survey is conducted and 205 valid questionnaires are collected. These questionnaires analyze the current situation of entrepreneurs implementing new media supported by AI technologies to gain scientific knowledge. Finally strategic suggestions are proposed to communicate science knowledge to entrepreneurs in an intelligent media context.