Abstract: Derogation of personal information rights in scientific research information processing activities will help promote the rational use of personal information and consolidate the cornerstone of the rule of law for digital China. Based on the in-depth analysis of the derogation of personal information rights in scientific research information processing activities, the paper clarifies the legitimate basis and basic principles of the derogation of personal information rights, and puts forward reasonable suggestions for the system construction of the derogation of personal information rights. In order to ensure the legitimacy of derogation of personal information rights in scientific research information processing activities, the scope of derogation of personal information rights should be appropriately framed through laws and regulations. The content of derogation of personal information rights should be reasonably constructed through benefit measurement. The procedural design of derogation of personal information rights should be scientifically constructed through benefit communication. It is in the public interest to ensure the derogation of personal information rights through judicial review.