Abstract: Manufacturing intelligentization is an important driving force for building a powerful manufacturing country and cultivating new industrial competitive advantages. How to optimize the doing environment and promote the intelligent development of manufacturing industry is an important issue that needs to be solved at present. Based on the perspective of configuration, the study adopts the research method of combining NCA and QCA, and takes 30 provinces in China as research samples to explore the diversified driving path of ecosystem of doing business to manufacturing intelligentization. It shows that a single doing business condition is not a necessary condition to produce high manufacturing intelligentization. High manufacturing intelligentization is affected by the "multiple concurrent" of six conditions, namely, government environment, market environment, innovation environment, financial services, public services, and human resources, forming three configuration paths, which can be specifically summarized as the financial and resource-driven path, the market-helping path combining resource-driven ,and innovation environment, the innovation-driven path under government-dominant. By further exploring the spatial situation difference of the research samples, it can be seen that the driving path of manufacturing intelligentization in developed and underdeveloped regions is significantly different. Based on the perspective of configuration，the study systematically explores the driving path of doing business to manufacturing intelligentization, providing decision reference and practical guidance for improving the development of manufacturing intelligentization.