Abstract: The interdisciplinary entrepreneurial team is the key carrier for universities to carry out academic entrepreneurship. Strengthening the internal governance of the interdisciplinary entrepreneurial team in universities is an important measure to enhance the transformation of scientific and technological achievements in universities and boost the construction of the national innovation system. The interdisciplinary entrepreneurial team in universities is the source of the improvement of academic entrepreneurial performance, there is still a lack of systematic and comprehensive theoretical and empirical research on its internal governance. This paper takes interdisciplinary entrepreneurial teams in universities as the study object, analyzes the internal governance mechanism and laws of interdisciplinary entrepreneurial teams in universities theoretically and empirically, and finds that: Transformational leadership has positive impacts on interdisciplinary collaboration and academic entrepreneurial performance in interdisciplinary entrepreneurial teams in universities; Interdisciplinary collaboration plays a partial mediating effect in the relationship between transformational leadership and academic entrepreneurial performance; The relationship conflict in conflict plays both a negative and a positive moderating effect in the relationship between transformational leadership and the different dimensions of interdisciplinary collaboration. The task conflict in conflict has an insignificant negative moderating effect in the relationship between transformational leadership and the quality of collaboration in interdisciplinary collaboration. The findings of this paper emphasize the matching law of the materialization process of the productivity of interdisciplinary entrepreneurial teams in universities, and also provide evidence for the coupling of core elements in the internal governance process of interdisciplinary entrepreneurial teams in universities. The theoretical contribution of this paper are as follows: firstly, there has been controversy over the dimensions of transformational leadership in previous studies. This paper confirms that transformational leadership is a univariate variable and cannot be divided into different dimensions, indicating that there may be important situational elements in the dimension division of transformational leadership. Secondly, based on the interdisciplinary characteristics of interdisciplinary entrepreneurial teams in universities, this paper explores the integration of transformational leadership and interdisciplinary cooperation, two key governance elements that affect the growth and development of interdisciplinary entrepreneurial teams in universities, into the common research model. This not only expands the analytical framework for the performance of transformational leadership in academic entrepreneurial teams, but also systematically depicts and describes the internal governance mechanisms of interdisciplinary entrepreneurial teams in universities, this goes beyond the existing study framework on the separation of transformational leadership and interdisciplinary cooperation, it is an important supplement to both transformational leadership theory and interdisciplinary cooperation theory. Thirdly, this study finds that there are significant differences in the moderating effects of different dimensions of conflict in the relationship between transformational leadership and interdisciplinary cooperation, which breaks through the stereotype that relationship conflict always has a negative impact in previous studies, and is an important supplement to the conflict theory and the theory of competition and cooperation. The practical inspiration of this paper lies in: the paper focuses on the most important internal governance variable of the team-the key role of transformational leadership in the academic entrepreneurial performance of interdisciplinary entrepreneurial teams in universities. At the same time, this paper emphasizes that interdisciplinary cooperation is an important path to improve the internal governance performance of interdisciplinary entrepreneurial teams in universities. Moreover, the paper identifies the different roles that conflict plays in the process of transformational leadership leading interdisciplinary entrepreneurial team members in universities to engage in interdisciplinary cooperation.