Abstract: Innovation consortium is the strategic linchpin of the new national system, and the leadership of enterprises is an important way to form innovation consortium. How to build an innovation consortium with "fusion of interests, integration of elements and convergence of capabilities" to promote the deep coupling of innovation and industrial chains is an important research topic in the process of building an innovative country under the new situation. In this paper, we analyzed the characteristics of five management linkages and mechanisms of enterprise-led innovation consortia through case studies, and constructed a three-stage dynamic evolution model accordingly. It was found that: (1) corporate strategy renewal is the driving force of the innovation consortium; (2) binary organizational structure is the fulcrum of the relationship between the two chains; (3) real option thinking is conducive to incentive-compatible interest integration; (4) interactive learning mechanism is the key to the process of factor integration; (5) digital empowerment is the important support of capability integration. This paper constructs a three-stage evolutionary model of innovation consortium, analyzes the dynamic process and management ideas of deep coupling of innovation and industrial chains. Then aims to provide stable solutions for traditional enterprises in deep red sea competition, so as to comprehensively and safely promote S&T self-sufficiency and industrial autonomy.