Abstract: According to the traditional positivist, science, presupposing universalism of science because of Knowledge sharing for all humanity, is independent of society and politics, which provides the theoretical foundation for international cooperation of science. Nowadays, however, this view of Science has been challenged in international cooperation. Analysing the event of NASA “China exclusion” on scientific research, we can find that American government adopted many intervention modes, such as legislation, finance, to control scientific cooperation, and under the pretext of “National Security”, containment and blockade rising country including China, which set up obstacles for international cooperation in science. Facing the Challenge, we should strengthen the consciousness of the politicization of science in globalization era, safeguard the national security by competition and struggle in scientific research cooperation, meanwhile，we also should strengthen independent innovation and strive for more discourse power in international cooperation， which can really break the blockade by western countries in science and technology.