Abstract: This paper try to research two industrial clusters with different structures (homogeneous structure with no leading firms and heterogeneous structure with leading firms) and the comparative evolution of the respective clusters from three aspects of entry barriers, labor division levels and the innovation capacity. The research thus has the following conclusions: (1) compared with homogeneous structures, the heterogeneous structures’ scale is smaller, but the overall earnings will be higher when they become stable. (2)the heterogeneous structure clusters(those with leading firms) have higher labor division levels and more innovation capacity when compared with homogeneous structure clusters. (3) the research also finds that, with the appearance of leading firms and the increasing of entry barriers, entrepreneurship in the cluster may be suppressed(especially in new ventures), thus it would be harder than homogeneous structure clusters to develop new ventures, however, the welfare of the entire cluster would increase. It thus indicates that the development of leading firms will have complex effects on the clusters.