Abstract: Trans-provincial regional public S&T innovation service platform (Trans-provincial platform abbr.) is not only the blank of our country’s public S&T innovation service platform system, but also the national important power to promote the construction of public S&T innovation service platform, whose layout will directly affect the rationality of the allocation of trans-provincial regional public science and technology resources and the validity of its service. This paper, using the factor analysis, makes a study of the layout of trans-provincial platform of China's seven industry for empirical research. We find two results: “innovation resources supply level” and “innovation resources demand intensity” are the key factors to affect the layout of trans-provincial platform, especially the “innovation resources demand intensity” should be strengthened; we should arrange different types of trans-provincial platform in different regions.