Abstract: Using I-U cooperative patents of organic chemical industry, this paper analyzes the patent map and constructs negative binomial regression models based on unbalanced panel data, the models use enterprise’s independent innovation performance(IIP) as dependent variable. Through the models, this paper study how the enterprise’s relational potential energy (RPE) influence the IIP and inspect how the geographic boundary spanning of enterprise’s cooperative network moderates the relationship between RPE and IIP. The results show that organic chemical industry has grown slowly in recent years and geographic boundary is spanning, the direct tie scale and the indirect tie strength both have positive effects on IIP, the geographic boundary spanning moderates the relationship between the indirect RPE and IIP.