Abstract: Based on quantifying S&T policy, this paper measured the characteristics of the S&T policy mix, described their trends and carried on the analysis of the influence of S&T policy mix on the innovation of high-tech industries during 1995-2013 using the Negative Binomial Regression Model. The paper studied the policy mix both of different kinds of S&T policy and of different polices in the same kind, and has found that: the comprehensiveness and the consistency of S&T policy mix showed growth trends generally and had a positive role to innovation; the balance of the mix of different kinds of policy tools showed an obvious growth and then became stable, while the balance of other policy mixes was lower and did not have obvious growth trends, and the effects of the balance were less stable; the impacts of policy mix on industrial innovation had regional differences, the difference of comprehensive and consistency was only in the degree, the difference of balance was both in the degree and in the direction , and the effects of the integrated coastal economic zone in the south were better than other zones in general.