Abstract: The innovation cluster area integrates a large number of innovation subjects, and provides an excellent network of innovation resources for technology entrepreneurship. This paper explored the mechanism by which technology start-ups’ resource heterogeneity promoting network routine established, and further acquiring network resources. The moderating effects of innovation cluster have also been tested. On the basis of the related literature, the proposed theoretical hypotheses’ model was empirical tested by means of a questionnaire survey conducted on 417 start-ups and Multiple Linear Regression．The results indicated that, in the three dimensions of resource heterogeneity, scarcity and imitating difficulty significantly affect the network routine establishment. Network routine has showed different effects on acquiring results of different type resources. The tacit understanding in cognitive and action levels obviously improved the efficiency of knowledge capital acquisition, but not for asset resources. The innovation cluster effects positively moderated the relationship between "resource heterogeneity – network routine establishment - knowledge resource acquisition".