Abstract: Derivation model is one of the important ways to develop and form industry. The paper absorbs rational theory kernel including evolution economics theory, theory of institutional change, constructivism theory and entrepreneurship theory, and which puts forward the theoretical hypothesis on the importance of historical evolution, satisfactory decision, entrepreneurship, derivative development power, active constructivism, and which constructs a conceptual model of the derived model from the perspective of integration based on heterogeneous human capital leading entrepreneurship as the core, and which theoretically and normatively expounds the mechanism of industry derivation development. Finally, the paper takes industry derivation development of Zhongguancun in Beijing as an example to makes a case interpretation.