Abstract: the problem how to collaborate online/offline innovation is the enterprise to face when adapting to the development of the Internet. Collecting the data from small and medium-sized manufacturing enterprises in zhejiang province, we used the method of qualitative comparative analysis on the behavior of online/offline innovation integrated analysis, the study found that China's online/offline innovation synergy drive mechanism can be divided into four kind of configurations, PS * PO * HC, GD * PS* PO, GD * PO * R&D and PS * R&D, and the enterprise information acquisition ability is very important in all four configurations of driving factors, the enterprises need to make full use of network and coordinated the relevant factors, and the allocation of resources to achieve synergies of online/offline innovation.