Abstract: Entrepreneurship has become an important economic and social research topic all over the world. Many studies have shown that entrepreneurship can be taught. However, the previous scholars' conclusions about the relationship between entrepreneurship education and entrepreneurial intention are inconsistent and need to be reexamined. Based on the theory of planned behavior, this paper constructs a multiple mediating effect model of entrepreneurial education on entrepreneurial intention. The questionnaire survey data of eight provinces were collected and analyzed by using SPSS and AMOS software. The results show that the entrepreneurship education has a positive impact on the entrepreneurial intention, the three cognitive factors of the theory of planned behavior (control of entrepreneurial attitude, subjective norm and perceived behavior) plays a mediating role between entrepreneurial education and entrepreneurial intention. This study extends the application of the theory of planned behavior in the research field of entrepreneurship, Enriches the existing research literature on entrepreneurship education, provides a theoretical basis for construction of entrepreneurship education ecological system, encourages students to start their own businesses, and boosts the development of innovational and entrepreneurial economic in our country.