Abstract: Abstract: Culture is particularly important as a soft power of competition in nonprofit organizations. This paper attempts to reveal that nonprofit organizational innovation is not dependent on the strength of a condition variable in a nonprofit organizational culture, but on the combination of different condition variables. Based on the analysis of 23 nonprofit organizations in Beijing, this paper employs qualitative comparison analysis (QCA) to explore the effect of nonprofit organization culture on organizational innovation. Results showed that: Firstly, the cultural foundation of non-profit organization innovation is a combination of two elements: high participation and high adaptability. Secondly, High participation * High adaptability * High mission or High participation * High adaptability * High consistency is a necessary condition for organizational innovation. To a certain extent, the high mission of non-profit organization cultural elements can replace the high consistency. But beyond a certain threshold, the substitution will no longer work. Thirdly, the final score of organizational innovation brought by the same non-profit organization cultural factor combination score may be the same, but the internal indicators of organizational innovation are different. The study proposes to strengthen the adaptability and participation in the organizational culture of non-profit organizations, to promote organizational innovation in collaboration with the cultural factors of non-profit organizations, and to vigorously cultivate the innovative cultural environment of non-profit organizations.