Abstract: This article aims to research the affection of the knowledge spillover from international to the economic growth in china based on the panel data of 2004~2015 through the method of spatial panel data model. The results show that From an overall perspective，independent innovation，foreign investment and export trade can significantly promote regional economic growth. However，only import trade can significantly improve total factor productivity. In the eastern region，independent innovation，foreign investment，import trade and export trade can significantly promote regional economic growth While the import and export trade has a positive impact on the total factor productivity. The independent innovation and foreign investment will promote economic growth，while foreign investment，foreign investment and import trade will enhance the total factor productivity in the central region ； For the western region，independent innovation and import trade can significantly promote regional economic growth，while import trade can significantly improve total factor productivity. Based on those finding，the paper put forward some related policy suggestions that the regions should be taken of the different economic policy.