Abstract: The implementation and management of disruptive technological innovation project are the focus of governments, academia and industry. Firstly, this paper reviews important concepts relevant to disruptive technological innovation and proposed the mechanism of it based on the evolution of science, technology and industry. Then this paper takes the Defense Advanced Research Projects Agency as an example, it refining and summarizing the key path and practice by sorting out the DARPA's project to develop disruptive technologies. Finally, it provides policy advice for subversive disruptive technological innovation in China's context.