Abstract: The transformation of social and economic development from "scale and efficiency" to "value and meaning" is an important indication of human society development in the new era. As an innovation paradigm that guides enterprises to focus on social demands and the future, Meaningful innovation (MI) shows the "return" of humanistic spirit and philosophical thinking in the economic field. In today's society where business civilization and science and technology are highly developed and interacted, the external environment faced by enterprises is a highly Complex Adaptive System (CAS). In this framework, the antecedents of meaningful innovation are explored. The discovery of innovation meaning is conceptualized as a process of exploratory learning while the transition of it is a process of exploitation. On this basis, in the face of resource constraints and environmental challenges, it is proposed that enterprises should develop "Ambidextrous Innovation Capability" to realize resource synergy, give consideration to short-term benefits and long-term development, coordinate efficiency logic and meaning-based logic, balance enterprise interests and social welfare, and promote the sustainable development of social economy and culture.