Abstract: Abstract: It is an important way to promote regional development under the background of "the new normal" which promoting regional innovation performance by taking the opportunity of deep integration of military and civilian. In view of this, this paper constructs the weight of geographical distance and economic distance, and establishes the dynamic space panel model to test the influence effect of civil-military integration on the regional innovation performance with the panel data from 2007 to 2017 by integrating the data in 209 military companies listed companies. The results show that: (1) The integration of military and civilian is conducive to enhancing regional innovation performance, however, there is “space competition” in the regional innovation performance improvement effect of military and civilian integration in neighboring regions. (2) There is significant regional heterogeneity in the driving effect of military-civilian integration on innovation performance，it is effective to improve innovation performance by deepening the integration of military and civilian in the strong military-civilian integration area . (3) The difference in regional endowment restricts the spatial spillover effect of military-civilian integration，It can guarantee the improvement of overall innovation performance by “strong alliance” between the strong military-civilian integration area and others, but it inhibits the spillover effect between the weak military- civilian integration areas and others. So, this paper proposes that we should deepen the “distribution service”, and ensure the accuracy of policies, to promote the integration of the military and the people, and enhance the regional innovation performance.