Abstract: Through the combing of the transdisciplinary concept, it is considered that the transdisciplinary is the knowledge innovation based on the model 3 knowledge production, covering the coding knowledge and the tacit knowledge, breaking through the inherent knowledge boundaries of each single discipline and the discipline itself. There is no paradigm in transdisciplinary, and complexity studies are its common academic hard core. In the information network society, the transdisciplinary focus on the integration of subject and non-disciplinary knowledge, focusing on the integration between different levels, is a multi-level, multi-dimensional knowledge cluster. The transdisciplinary nature of human settlement science lies in the complexity, multidimensionality and multi-values of human settlements. The concept of human settlements contains almost all the life of human society, and the lines of sight of different disciplines can overlap on the subject of "human settlements". Human habitation is a booster that human beings differentiate from nature and is independent of the world. It is an important foundation for the formation of human thinking and the formation of values. Habitat science is a process in which researchers, designers, builders, users, etc. jointly express new aspirations, jointly achieve a consensus from theory to method, and jointly generate new knowledge. The transdisciplinary nature of human settlement science is an open academic system with complex research as the core, human settlement system and social information network system, and a large number of knowledge clusters and discipline clusters as the main body.