Abstract: It has been long term concerned that the innovation and entrepreneurship of universities usually fall into the path-dependence. Extant studies prefer to interpret it as a result of institutional inertia, while in this study, we bring the framework of reciprocal structuration theory, and employ a grounded theory by a case study of University E building Smart City J. We reveal that there is double path-dependence during the process of innovation and entrepreneurship by universities. To be specific, due to the exogenous and interpretative flexibility, technologies are usually loaded on specific technical logics and institutional structures, while subject to multiple identities and legitimacy requisition, universities are inclined to re-couple the exist structures, or reload other compatible structures, but not challenge or rebuild the existing path or structures. What is more, the micro process of double path-dependence relies on the organizational scripts which implement the reciprocal structuration of technology and society. Therefore, we argue that the importance of technology, especially the socio-technical perspective, as well as the micro-foundation of organization scripts, should be drawn more attentions in the future innovation studies.