Abstract: As an outstanding scholar with great influence in the field of science, Liu Zeyuan has been committed to research of science of science for many years and has played an important role in participating in major national scientific and technological projects. Mr. Liu has made great contributions to the development and innovation of Chinese science of science. He also has his own unique and profound views on the research of science of science, and has made pioneering achievements in many directions, such as philosophy of technology, ethics of science and technology, scientometrics, and innovation management. In order to remember and commemorate Mr. Liu, this paper reviews his outstanding achievements in the field of science of science, summarizes the academic achievements of him and his team in the field of science of science, and sorts out and summarizes his academic contributions. This paper also makes a brief analysis of Mr. Liu's academic papers published in the past 40 years from the perspective of time, and discusses the evolution and changes of his academic thoughts of science of science based on the theme of his academic papers and his research directions in various periods. With this theme, we hope that the scientific community can develop more scientific theories, enrich research methods, expand the application fields of science of science, and write a new chapter for the cause of science of science.