Abstract: Most of the public health emergencies occurring repeatedly in history are consequences of the disorder of the “One Health”, behind which lies the epistemological misunderstanding of human-animal binary. The hierarchy between rational man and animal machine leads to the domination and control of “self” to “others”, encouraging human’s trample on animals and the environment. However, while humans wantonly kill animals, animals retaliate with the same way. This very “general mobilization” against the virus is derived from the collapse of the human-animal relationship in the universal-connected health network. This outbreak would just be a dress rehearsal for the next crisis, if serious reflection on the epistemological misconceptions are not made. Only by dismantling dualism and establishing the extensive cooperation can humans co-habitat and co-evolve with animals, living in the “One World” and sharing with “One Health”.