Abstract: The technological and economic decoupling between China and the United States further highlights the urgency of China's key technological innovation breakthroughs. This paper constructs the key technology classification system from the two dimensions of the key technologies: characteristic of technical law and the development level of this technology in China. Furthermore, from the perspective of innovation ecosystem, the organization modes and R&D modes suitable for different types of key technologies are further summarized. We find that the national system mode with strong government intervention is suitable for the aggregate technologies; The industry-university-research cooperation mode with more autonomy is suitable for the bottleneck technologies; the core enterprise leadership mode driven by entrepreneurship is suitable for the open technologies; the flexible and open nonprofit-led mode is suitable for the exploratory technologies. The conclusion of this study provides theoretical reference for the organization mode design of key technologies and government policy making in China.