Abstract: Convergence research is a paradigm of scientific research based on interdisciplinary to solve major problems, which has been highly valued by major countries in recent years under the background of intensified international technology competition. Due to differences in concepts and methods, this paradigm of "convergence research " is significantly different from that of the past. Based on a combination of quantitative and qualitative method, this article takes the star drug—epoetin alfa as a case, and uses retrospective analysis to map the drug's R&D evolution trajectory and describes the " convergence research " characteristics reflected in this trajectory ,and then extracts the characteristics of the convergence research. This article lay the foundation for promoting the development of convergence research and better solving the major problems facing China and even all mankind.