Abstract: Accelerating the development of science-based industries and cultivating emerging industries and future industries based on breakthroughs in scientific theories are the key to fight the battle of core technologies and transform to high-quality development. It is urgent to clearly define and screen industries and deeply explore the innovation law of industries. However, the academic research on "science based industry" is not deep enough, and the existing screening method of "industry science correlation index" has many limitations. Therefore, it is very necessary to expand the index dimension of quantitative screening of science-based industries. This study expanded the quantitative screening dimension of science-based industries on the basis of "industry science correlation index". On the basis of theoretical research, we introduced several indicators, and determined the rationality of the selected indicators through the analysis of the differences between the two typical industries (science-based industry and technology-based industry), and finally formed a quantitative screening paradigm of science-based industry. According to the existing research of scholars, we selected five sub industries from the typical "science-based industry" and "technology-based industry". From the Incopat patent database, we have obtained 29521 patents from 10 sub industries in the past five years, and carried out a detailed calculation of the data to explore the differences in indicators between the two types of industries. Finally, we determined three indicators, i.e. "ISPI（Industry Science Participation Index）", "ISTI（Industry Science Time interval Index）" and "ISSI（Industry Science Scientist Participation Index）", and in these indicator dimensions, there are significant differences between"science-based industry" and "technology-based industry". The results shows that "science based industry" tends to have a high degree of integration of industry and science subjects, and public institutions are important sources of innovation; It has a short time interval between industry and science, the transformation from basic science to technology patent is faster, and the ability to absorb knowledge is stronger; "Science based industry" tends to have a high degree of industry science subject transformation, scientists possess both scientific achievements and patent outputs. On this foundation, we expanded the quantitative screening method of science-based industry, and constructed a set of "four-level tendency" industrial quantitative discrimination paradigm, which provided a theoretical basis for subsequent industry research and had certain theoretical contributions. This study can provide theoretical reference for subsequent scholars to study on "science-based industry", and simplify data operation to a certain extent, so as to avoid the lack of rigor of the research conclusion due to the deviation of industry definition. Therefore, it has certain theoretical contributions. Meanwhile, the research conclusions can provide management enlightenment for the development of "science-based industry" in China.