Abstract: As the leader of the market segment in the future, SRCN enterprises (Small and medium-sized enterprises with the characteristics of specialization, refinement, characterization and novelty) play an important role in breaking through the key technological bottlenecks and maintaining the stability of the global industrial chain. However, in the highly uncertain market environment, especially in the context of epidemic and anti-globalization, how to smoothly survive the crisis and achieve sustainable development for SRCN enterprises has become the focus of current managers. Based on the resource-based view and the perspective of dynamic capabilities, this paper constructs a chain intermediary model to explore the impact mechanism of entrepreneurial orientation on the performance of SRCN enterprises, and further uses the data of 372 SRCN enterprises for empirical analysis. The research finds that: (1) entrepreneurial orientation has a significant positive impact on the performance of SRCN enterprises; (2) entrepreneurial bricolage and organizational resilience play a synchronous and chain intermediary role between entrepreneurial orientation and the performance of SRCN enterprises. The research conclusion is of great theoretical significance for the success of SRCN enterprises, as well as practical significance for the survival and development of SRCN enterprises under the domestic and international double cycle background.