Abstract: The knowledge mapping has became one of the most important methods, the reliability testing of this method were still remaining the comparison between results and classical cases. The study gave a comparison between highly cited paper and uncited papers on three network indicators for the aim to test the reliability of co-word analysis. Three indicators were nodes degree, nodes betweenness centrality and isolated nodes base on bibliographic coupling network according to high frequency keywords，which were the citing paper regression of co-word network. The results showed that though the high frequency keywords involved more highly cited papers, there is a little uncertainty in the nodes evaluation according three network indicators. This paper also gave a discussion on the application of thesaurus and data collection of knowledge mapping.