Abstract: Based on literatures on innovation ecosystem, this paper attempts to straighten up the difference and relation between researches under multiple levels. Paying close attentions to "interdependence between the subjects" emphasized by innovation systems theory and "the subjects’ interaction with the environment" emphasized by ecology, it establishes that a “Core-Periphery” fame to contain the components of innovation ecosystem. By analysising the changes of subjects’ (central) and environment’s (peripheral) scopes on micro meso and macro levels, this paper reveals the connotations, structure and behavior that innovation ecosystem on different levels contained, and the cross-level interactions. At last, some recommendations are made for the studies and practices.