Abstract: Disruptive innovation (DI) is perceived to be an effective strategy for technological small and micro enterprises (TSMEs) to compete with incumbent firms. Though Market is critical for successful development of disruptive innovation, the relationship between multi-dimensions of market knowledge and disruptive innovation did not get enough research attention. Based on data collected from 364 technological small and micro enterprises in Foshan district, Guangdong Province, the paper empirically analysis the aforementioned relationship. The results indicate the following: First, the breadth and depth of market knowledge have a direct significant influence on DI of TSMEs respectively. Second, the tacitness and specificity of market knowledge have a indirect significant influence on DI of TSMEs respectively. Third, knowledge integration capabilities (KIC) fully mediate the impact of the breadth and depth of market knowledge on DI of TSMEs, and partially mediate the impact of the tacitness and specificity of market knowledge on DI of TSMEs. Moreover, the multi-dimensions of market knowledge have a significant effect on KIC, which means capture and access multi-dimensional market knowledge is helpful for the TSMEs to strength their KIC.