Abstract: There is no doubt that knowledge creation between enterprises in supply chain is a keyword in obtaining competitive advantage. Based on the system perspective and combined with the analysis of existing research, enterprises’ interview, the paper proposes 18 influential factors of knowledge creation between enterprises in supply chain. Then a Fuzzy DEMATEL method is used to research the causal-effect category and the importance of each factor quantitatively. Showing that the “expected value of the knowledge” is the most important factor in causal group and “the willingness and the tendency of cooperation” is the most important factor in effect group, the results divide factors into two types. In addition, the paper also obtains 7 key factors on the basis of the analysis on the score of the degree of influence, the degree of being influenced, the degree of causal and the degree of centrality in each factor. Finally the paper provides advices to the practice of knowledge creation between enterprises in supply chain under the situation in China.