Abstract: Taking 77 Chinese Academy of Sciences (ACAS) and 82 Nobel prize laureates in physiology or medicine as research samples，the study of classification of scientists is conducted based on 2-dimensional coordinate space. Two-dimensional coordinate systems between average and high level of papers impact, and between impact level and variation degree of papers are set up, and demonstrate the application value in the management of scientific research. To reach the level of Nobel prize as a whole, ACAS’ paper impact needs to expand e2 times, although a few ACAS have reached the Nobel prize level.