Abstract: The newly incubated startups implement entrepreneurial orientation and innovative drive strategies facing high risks, high failure ratios and high heterogeneity, and how to practice innovation and entrepreneurship step by step steady win, which has aroused academic community to explore the issue. On the basis of theories of network routine and knowledge spiral, this paper establishes the “Entrepreneurial orientation and innovative drive --- Network routine --- Enterprise performance and capability” structural equation model, and carries out empirical analysis using the samples of newly incubated startups in Chinese context Tianjin six areas and the surrounding areas. The results show that the innovative drive, entrepreneurial orientation and network routine respectively affect the enterprise performance and capability positively and significantly, and the innovative drive and entrepreneurial orientation respectively affects the network embedding positively and significantly, and the network routine generates partial mediating effects, and the knowledge spiral positively adjusts the mediating effects of network routine, and further study the affect difference of the different levels of knowledge spiral development capacity.