Abstract: The new round of industrial revolution led by AI has brought about the prominence of innovation network new characteristics, including multi-system sharing and opening, multi-agent interaction and complementarity, multi-factor oscillation and interweaving. It causes the dual demand of industry-university-research institute synergy innovation （IURSI） for resource heterogeneity and knowledge flow. This paper takes AI industry for example, and discusses dynamic interaction effect of resource heterogeneity and knowledge flow on IURIS. The results show that: The resource heterogeneity plays a significant role in promoting IURIS. However, with the continuous development of the industrial life cycle, knowledge absorption to this promoting role has undergone a dynamic process of "greater negative moderating effect-smaller negative moderating effect-stronger positive moderating effect", and knowledge diffusion to this promoting role has undergone a process of "small positive regulation effect-negative regulation effect appears-negative regulation effect increases". These discoveries provide reference for finding the breakthrough point of AI IURIS’s governance., The new round of industrial revolution led by AI has brought about the prominence of innovation network new characteristics, including multi-system sharing and opening, multi-agent interaction and complementarity, multi-factor oscillation and interweaving. It causes the dual demand of industry-university-research institute synergy innovation （IURSI） for resource heterogeneity and knowledge flow. This paper takes AI industry for example, and discusses dynamic interaction effect of resource heterogeneity and knowledge flow on IURIS. The results show that: The resource heterogeneity plays a significant role in promoting IURIS. However, with the continuous development of the industrial life cycle, knowledge absorption to this promoting role has undergone a dynamic process of "greater negative moderating effect-smaller negative moderating effect-stronger positive moderating effect", and knowledge diffusion to this promoting role has undergone a process of "small positive regulation effect-negative regulation effect appears-negative regulation effect increases". These discoveries provide reference for finding the breakthrough point of AI IURIS’s governance., The new round of industrial revolution led by AI has brought about the prominence of innovation network new characteristics, including multi-system sharing and opening, multi-agent interaction and complementarity, multi-factor oscillation and interweaving. It causes the dual demand of industry-university-research institute synergy innovation （IURSI） for resource heterogeneity and knowledge flow. This paper takes AI industry for example, and discusses dynamic interaction effect of resource heterogeneity and knowledge flow on IURIS. The results show that: The resource heterogeneity plays a significant role in promoting IURIS. However, with the continuous development of the industrial life cycle, knowledge absorption to this promoting role has undergone a dynamic process of "greater negative moderating effect-smaller negative moderating effect-stronger positive moderating effect", and knowledge diffusion to this promoting role has undergone a process of "small positive regulation effect-negative regulation effect appears-negative regulation effect increases". These discoveries provide reference for finding the breakthrough point of AI IURIS’s governance.