Abstract: Precision medicine is one of the new types of modern medicine premised on human genome sequencing, guaranteed by the life medical data sharing, and grounded in the global change (and globalization). Its birth and development provide the material basis, lay information foundation and develop reality for maintaining overall human health. The construction of precision medicine ethics should be based on analyzing the organic connections and internal logical relationships between individual health and humankind health, shaping the ethical conception of “a community with a shared healthy future for mankind”, and obeying the ethical principles of protecting privacy, co-building and sharing precision medicine system, jointly shouldering the responsibility and governance. The paths to carry it out are as follows: to formulate ethical norms of precision medicine, to strengthen the ethical training for practitioners in the field of precision medicine, to promote ethical review and supervision of the entire process of precision medicine, and to accelerate the development and implementation of precision medicine laws and regulations. This research made a macro-consideration on the general direction and key issues of the construction of precision medicine ethics.