Abstract: Based on the perspective of SME performance, with the help of the related theories of organizational change, this paper makes an empirical analysis of the intelligent manufacturing situation of 472 SMEs by using layer-by-layer regression model. The research results show that the manufacturing and maintenance intelligence of intelligent manufacturing has a significant positive impact on the performance of SMEs. At the same time, the organizational changes in different dimensions within the enterprise play a regulatory role in the relationship between manufacturing dimension, intelligent dimension and SME performance. Moreover, this adjustment effect is different, organizational strategy, business process change and manufacturing dimension matching, organizational structure change and intelligent dimension matching will have a more significant positive impact on SME performance. Based on the above research findings, this paper gives suggestions for SMEs to achieve intelligent manufacturing.