Abstract: How to effectively build an internal entrepreneurial culture in a super-competitive environment and continue to promote the company's spontaneous entrepreneurship is of great significance to the strategic rejuvenation and reshaping of the enterprise. Based on the theory of social exchange, 584 employees of 67 companies are the research objects, and the employee's professionalism and organizational status perception are introduced to analyze the mechanism of entrepreneurial culture on the company's entrepreneurship. The research results show that entrepreneurial culture and employee engagement have a significant positive impact on the company's entrepreneurship; employee engagement plays a part in mediating between entrepreneurial culture and corporate entrepreneurship, and further discovers that perceived organization status positively regulates the relationship between entrepreneurial culture and employee engagement, and positively adjusts the intermediary effect of employee engagement.