Abstract: As the body of technological innovation and entrepreneurship activities, technological entrepreneurs have the characteristics of team leaders and highly creative individuals. Most researches focus on the technical level, but the research on the special heterogeneity of human capital, especially political skills, of the technological entrepreneurs are slightly insufficient. Based on the theory of human capital, this paper focuses on 454 technological entrepreneurs in Beijing, Shanghai, Guangzhou, Zhejiang and Henan, focusing on the impact of technological entrepreneurial political skills on innovation performance, and examines the impact process. The empirical results show that: (1) the political skills of technological entrepreneurs has a signifcantly negative e?ect on innovation performance of enterprises; (2) Transactive memory system of entrepreneurial team play a partial mediating effect between the political skills of technological entrepreneurs and innovation performance; (3) Entrepreneurs' personal reputation positively moderates the direct predictive role of technological entrepreneurs’ political skills and innovation performance and the mediating role of transactive memory system in the relationship between them.