Abstract: Although the value of knowledge to innovation ability and the influence of power on work attitude have been fully demonstrated, the complex interaction between power and knowledge in the context of entrepreneurial organization has not yet been fully revealed. Through empirical research, this paper explores the coupling relationship between power and knowledge of entrepreneurial organizations, and the mechanism and path of influence on innovation attitude, innovation ability and innovation performance. A meaningful conclusion is reached that the coupling effect of power and knowledge influence the interaction between innovation attitudes and innovation capabilities by means of innovation attitudes, and ultimately affecting innovation performance. It is more conducive to improving innovation performance and achieving innovation-driven high-quality development that entrepreneurship organizations avoid noise interfering from position power with innovation activities as far as possible, and give full play to the role of coupler between professional power and knowledge, in order to promote information circulation and knowledge utilization.