Abstract: Serial entrepreneurial action and its characteristics reflect the dynamic characteristics in the process of re-entrepreneurship, which determines the success of entrepreneurship. The importance of serial entrepreneurial action has attracted the attention of academics and industry, However, the research on what factors affect the serial entrepreneurial action is relatively lagging behind. Based on the grounded theory, this paper constructs the dimension of serial entrepreneurial action from the perspective of the effect of continuous entrepreneurship action.. This study extracts the influencing factors of serial entrepreneurial action through case studies of serial entrepreneurs such as Ma Yun, Shi Yuzhu, and Ren Zhengfei. Based on the interpretative structural model, this study deeply analyzes the intrinsic logical relationship and its hierarchical structure among the influencing factors. This study proposes that entrepreneurship is the driving force to promote serial entrepreneurial action, entrepreneurial learning is the foundation of serial entrepreneurship, emotional management is the necessary condition for serial entrepreneurship, and entrepreneurial capital is the guarantee of serial entrepreneurship, which helps to provide theoretical supplement and practical guidance for the theory of serial entrepreneurship.