Abstract: In the development of global innovation network, international talents are the key elements of organizational knowledge innovation, reinventing organizational knowledge structure and promoting the influence of organizational knowledge innovation. Taking artificial intelligence as an example, this paper analyzes the impact of international talents on organizational knowledge creation based on USPTO and WOS database. Through social network analysis methods, it depicts the characteristics of scientific cooperation network and patent cooperation network, and further studies the impact of international talents on the organization’s position in the knowledge network. The results show that international talents have a significant positive impact on the organization’s creation of new scientific knowledge, and have a significant positive impact on the organization’s position in the knowledge innovation network. The main contribution of this paper is to verify the important role of international talents in the creation of new knowledge form the perspective of science and technology cooperation network, and to open up the black box of the impact of international talents on knowledge network potential of organization. This has an important practical significance for China to build a global innovation network.